Experimental treatment was applied to mice, significantly reducing severe inflammatory symptoms. For people, you can use a similar approach, scientists are sure.
Crohn’s disease is characterized by chronic inflammation of the intestine, in which the immune system attacks the tissues of the gastrointestinal tract. Today, there is only supportive therapy for this disease. In search of an effective method of treatment, American scientists from the University of Cayes discovered a pathway in the immune system, the effect on which reduces the symptoms of the disease.
In experiments with mice prone to developing Crohn’s disease, scientists tried to understand the interaction between a class of proteins called tumor necrosis factor (TNF) and Fn14 receptors. They, on the one hand, can protect the intestines from inflammation, and on the other, provoke it. Experiments showed that in mice with removed Fn14, the inflammatory process was less pronounced.
To verify the potential results for treating people, scientists tested tissue samples from patients with chronic intestinal inflammation and found that they had overexpression of TNF/Fn14.
“Blocking Fn14 with antibodies or new drugs can reduce inflammation and tissue fibrosis in people with Crohn’s disease,” said Fabio Cominelli, author of the study.
Conclusions are also important for the prevention of cancer. Chronic inflammation in Crohn’s disease is known to significantly increase the risk of colorectal cancer.
Recently, scientists from the UK have proven that human stem cells can be modified to withstand Crohn’s disease. The new method is being tested in clinical trials. Researchers from the UK have proven that you can apply your own human cells against Crohn’s disease. The team has already successfully modified them and proved a potential effect, according to the website of the Center for Biomedical Research in London.
Crohn’s disease – a lifelong disease in which a person affects all parts of the gastrointestinal tract. It can cause a wide specter of gastrointestinal diseases: pancreatic cancer, gastritis, etc. Crohn’s disease usually is chronic and incurable.